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Research Studies is a compilation of published research articles funded by 大象视频or authored by 大象视频researchers.

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1 to 22 of 22 Research Studies Displayed
Yuh T, Lalley-Chareczko L, Zanders D
Acceptability and feasibility of implementing a home-based HIV pre-exposure prophylaxis program in an urban clinic.
This study assessed the acceptability and feasibility of a home-based HIV pre-exposure prophylaxis (PrEP) program among stakeholders at an urban HIV and primary care clinic. The authors surveyed and interviewed PrEP patients and their health care team, with a baseline of 112 PrEP users. Of those, 65% expressed interest in switching to the home-based PrEP program. Seventeen patients over the course of follow-up started home-based PrEP, including 12 patients who completed both a telemedicine visit and a self-administered lab kit, and 5 patients who completed only a telemedicine visit. Over 80% of those had positive feedback on the telemedicine visits. There was excellent acceptability and feasibility of the lab kits. There were mixed feelings from the 5 surveyed PrEP providers on telemedicine visits, but most felt that the program made PrEP care delivery easier for patients and would encourage their patients to use the program if it were a good fit. Barriers included shipping delays and staff turnover during program implementation.
AHRQ-funded.
Citation: Yuh T, Lalley-Chareczko L, Zanders D . Acceptability and feasibility of implementing a home-based HIV pre-exposure prophylaxis program in an urban clinic. AIDS Patient Care STDS 2024 Dec; 38(12):566-73. doi: 10.1089/apc.2024.0159.
Keywords: Human Immunodeficiency Virus (HIV), Prevention, Implementation, Telehealth, Health Information Technology (HIT)
Dukes KC, Hockett Sherlock S, Racila AM
Implementing nasal povidone-iodine decolonization to reduce infections in hemodialysis units: a qualitative assessment.
A qualitative study examined the implementation of nasal povidone-iodine decolonization in outpatient hemodialysis units to prevent bloodstream infections. Through interviews with 66 healthcare personnel across five U.S. academic medical centers, researchers found that while the treatment was generally acceptable and feasible, implementation success varied. Key facilitators included leadership support and patient engagement tools, while barriers included staffing limitations, patient health burdens, and language barriers. The findings suggest potential for successful implementation with appropriate organizational support.
AHRQ-funded; HS026724.
Citation: Dukes KC, Hockett Sherlock S, Racila AM . Implementing nasal povidone-iodine decolonization to reduce infections in hemodialysis units: a qualitative assessment. Infect Control Hosp Epidemiol 2024 Sep; 45(9):104-1109. doi: 10.1017/ice.2024.83..
Keywords: Healthcare-Associated Infections (HAIs), Prevention, Hospitals, Implementation
Barton HJ, Maru A, Leaf MA
Academic detailing as a health information technology implementation method: supporting the design and implementation of an emergency department-based clinical decision support tool to prevent future falls.
This study investigated the effectiveness of academic detailing, a method involving personalized education sessions with clinicians, in implementing a machine learning-based clinical decision support (CDS) tool designed to prevent future falls in elderly emergency department patients. Through qualitative analysis of interviews with clinicians who had encountered the CDS tool, researchers identified several factors influencing its use, including aspects of the tool's design, clinicians' understanding of the tool and referral process, the fast-paced emergency department environment, clinicians' perception of patient fall risk, and the complexity of the referral process. Academic detailing sessions allowed for real-time clarification of misconceptions and demonstration of the tool's functionality, highlighting its potential as a valuable strategy for supporting the implementation and optimization of health information technologies. Additionally, insights gained from these sessions can inform both immediate adjustments to the implementation process and long-term redesign of the tool to better align with clinicians' needs and workflows.
AHRQ-funded; HS027735.
Citation: Barton HJ, Maru A, Leaf MA . Academic detailing as a health information technology implementation method: supporting the design and implementation of an emergency department-based clinical decision support tool to prevent future falls. JMIR Hum Factors 2024 Apr 18; 11:e52592. doi: 10.2196/52592..
Keywords: Clinical Decision Support (CDS), Health Information Technology (HIT), Implementation, Emergency Department, Falls, Prevention
Lee BY, Bartsch SM, Lin MY
How long-term acute care hospitals can play an important role in controlling carbapenem-resistant Enterobacteriaceae in a region: a simulation modeling study.
Researchers investigated how implementing control measures in long-term acute care hospitals (LTACHs) can impact carbapenem-resistant Enterobacteriaceae (CRE) spread regionwide. They used their own Chicago metropolitan region agent-based model to simulate CRE spread and control. They found that a prevention bundle in only LTACHs decreased prevalence and averted new carriers, infections, and deaths over 3 years compared with no CRE control measures. When LTACHs and intensive care units intervened, prevalence decreased further. They concluded that LTACHs may be more important than other acute care settings for controlling CRE, and regional efforts to control drug-resistant organisms should start with LTACHs as a centerpiece.
AHRQ-funded; HS023317.
Citation: Lee BY, Bartsch SM, Lin MY . How long-term acute care hospitals can play an important role in controlling carbapenem-resistant Enterobacteriaceae in a region: a simulation modeling study. Am J Epidemiol 2021 Feb 1;190(3):448-58. doi: 10.1093/aje/kwaa247..
Keywords: Healthcare-Associated Infections (HAIs), Infectious Diseases, Prevention, Hospitals, Patient Safety, Implementation
Lee BY, Bartsch SM, Hayden MK
How to choose target facilities in a region to implement carbapenem-resistant Enterobacteriaceae control measures.
The authors investigated how best to choose the highest-yield facilities to target for interventions when trying to control regional spread of antibiotic-resistant pathogens such as carbapenem-resistant Enterobacteriaceae (CRE). They used their own Regional Healthcare Ecosystem Analyst-generated agent-based model of Chicago metropolitan area inpatient facilities to simulate the spread of CRE and to choose facilities to apply prevention bundles. They found that, while choosing target facilities based on single metrics (including most inpatient beds, most connections to other facilities) achieved better control than randomly choosing facilities, more effective targeting occurred when considering how these and other factors (including patient length of stay, care for higher-risk patients) interacted as a system.
AHRQ-funded; HS023317.
Citation: Lee BY, Bartsch SM, Hayden MK . How to choose target facilities in a region to implement carbapenem-resistant Enterobacteriaceae control measures. Clin Infect Dis 2021 Feb 1;72(3):438-47. doi: 10.1093/cid/ciaa072..
Keywords: Healthcare-Associated Infections (HAIs), Infectious Diseases, Implementation, Prevention, Patient Safety
Cykert S, Keyserling TC, Pignone M
A controlled trial of dissemination and implementation of a cardiovascular risk reduction strategy in small primary care practices.
Researchers assessed the effect of dissemination and implementation of an intervention consisting of practice facilitation and a risk-stratified, population management dashboard on cardiovascular risk reduction for patients at high risk in small, primary care practices. They found that a risk-stratified, population management dashboard combined with practice facilitation led to substantial reductions of 10-year atherosclerotic cardiovascular disease risk for patients at high risk. They recommended utilizing similar approaches to lead to effective dissemination and implementation of other new evidence, especially in rural and other under-resourced practices.
AHRQ-funded; HS023912.
Citation: Cykert S, Keyserling TC, Pignone M . A controlled trial of dissemination and implementation of a cardiovascular risk reduction strategy in small primary care practices. Health Serv Res 2020 Dec;55(6):944-53. doi: 10.1111/1475-6773.13571..
Keywords: Cardiovascular Conditions, Risk, Prevention, Primary Care, Implementation, Evidence-Based Practice, Patient-Centered Healthcare, Patient-Centered Outcomes Research
Whooten RC, Horan C, Cordes J
Evaluating the implementation of a before-school physical activity program: a mixed-methods approach in Massachusetts, 2018.
The aim of this study was to evaluate the implementation of a widely available, before-school, physical activity program in a low-resource, racially/ethnically and socioeconomically diverse, urban school setting to identify adaptations needed for successful implementation. The investigators used a collaborative effort with stakeholders to implement the Build Our Kids' Success (BOKS) program in 3 schools in Revere, Massachusetts.
AHRQ-funded; HS000063.
Citation: Whooten RC, Horan C, Cordes J . Evaluating the implementation of a before-school physical activity program: a mixed-methods approach in Massachusetts, 2018. Prev Chronic Dis 2020 Oct 1;17:E116. doi: 10.5888/pcd17.190445..
Keywords: Children/Adolescents, Education, Implementation, Health Promotion, Prevention, Lifestyle Changes, Social Determinants of Health
Knerr S, West KM, Angelo FA
Organizational readiness to implement population-based screening and genetic service delivery for hereditary cancer prevention and control.
Programs conducting population-based screening and genetic service delivery for hereditary cancer prevention and control are rare in practice. The authors interviewed individuals instrumental in implementing seven unique clinical programs conducting either universal tumor screening for Lynch Syndrome or routine family history screening and provision of genetic services for hereditary breast and ovarian cancer in the United States. Their findings suggest that developing interventions targeting change efficacy and cultivating practice change champions may be two promising ways to increase uptake of population-based hereditary cancer screening and genetic service delivery in clinical practice.
AHRQ-funded; HS022982.
Citation: Knerr S, West KM, Angelo FA . Organizational readiness to implement population-based screening and genetic service delivery for hereditary cancer prevention and control. J Genet Couns 2020 Oct;29(5):867-76. doi: 10.1002/jgc4.1216.
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Keywords: Cancer, Screening, Genetics, Prevention, Guidelines, Healthcare Delivery, Organizational Change, Implementation
Brault MA, Spiegelman D, Abdool Karim SS
Integrating and interpreting findings from the latest treatment as prevention trials.
This paper examined findings from some 2018-2019 international studies assessing the effectiveness of reducing HIV incidence by expanding HIV testing, linkage to HIV treatment, and helping persons living with HIV adhere to their medications (called the 90-90-90 strategy). A number of these 鈥渢reatment as prevention鈥 (TasP) tests had complex results. The studies examined included the TasP/ANRS 12249 study in South Africa, the SEARCH study in Kenya and Uganda, and one comparison (arms A to C) of the HPtn 071 (PopART) study in South Africa and Zambia as well as the Botswana Ya Tsie study. All but the Botswana Ya Tsie study and the second comparison (arms B to C) of PopART did not demonstrate a community impact on HIV incidence. But those two studies indicated significant (30%) reductions in HIV incidence in the intervention communities.
AHRQ-funded; HS023000.
Citation: Brault MA, Spiegelman D, Abdool Karim SS . Integrating and interpreting findings from the latest treatment as prevention trials. Curr HIV/AIDS Rep 2020 Jun;17(3):249-58. doi: 10.1007/s11904-020-00492-4..
Keywords: Human Immunodeficiency Virus (HIV), Prevention, Implementation, Medication, Screening
Ngo-Metzger Q, Mabry-Hernandez IR
大象视频Author: Ngo-Metzger Q, Mabry-Hernandez
Implementation of evidence-based recommendations for preventive services in the Veterans Health Administration.
The Veterans Health Administration (VHA) is the largest integrated health care system in the United States. To date, there has been scant research on how VHA adopts clinical preventive services guidelines and how U.S. Preventive Services Task Force recommendations factor into the process. In this study, the investigators conducted semistructured interviews with eight VHA leaders to examine how they adopt, disseminate, and measure adherence to recommendations. They concluded that provision of evidence-based clinical preventive services is an important part of VHA's effort to provide high-quality care for Veterans.
AHRQ-authored.
Citation: Ngo-Metzger Q, Mabry-Hernandez IR . Implementation of evidence-based recommendations for preventive services in the Veterans Health Administration. J Healthc Qual 2020 May/Jun;42(3):148-56. doi: 10.1097/jhq.0000000000000217..
Keywords: U.S. Preventive Services Task Force (USPSTF), Prevention, Evidence-Based Practice, Guidelines, Implementation
Sweeney SM, Hemler JR, Baron AN
Dedicated workforce required to support large-scale practice improvement.
Facilitation is an effective approach for helping practices implement sustainable evidence-based practice improvements. Few studies examine the facilitation infrastructure and support needed for large-scale dissemination and implementation initiatives. In this paper, the authors discuss a project by the Agency for Health care Research and Quality in which it funded 7 Cooperatives, each of which worked with over 200 primary care practices to rapidly disseminate and implement improvements in cardiovascular preventive care.
AHRQ-funded; HS023940.
Citation: Sweeney SM, Hemler JR, Baron AN . Dedicated workforce required to support large-scale practice improvement. J Am Board Fam Med 2020 Mar-Apr;33(2):230-39. doi: 10.3122/jabfm.2020.02.190261..
Keywords: Practice Improvement, Primary Care, Cardiovascular Conditions, Healthcare Delivery, Quality Improvement, Quality of Care, Prevention, Implementation, Evidence-Based Practice
Jiang V, Brooks EM, Tong ST
Factors influencing uptake of changes to clinical preventive guidelines.
Despite widespread recognition that adherence to clinical preventive guidelines improves patient outcomes, clinicians struggle to implement guideline changes in a timely manner. Multiple factors influence guideline adoption and effective implementation. However, few studies evaluate their collective and inter-related effects. This qualitative study provided a comprehensive picture of the interplay between multiple factors on uptake of new or changed preventive guidelines.
AHRQ-funded; HS025032.
Citation: Jiang V, Brooks EM, Tong ST . Factors influencing uptake of changes to clinical preventive guidelines. J Am Board Fam Med 2020 Mar-Apr;33(2):271-78. doi: 10.3122/jabfm.2020.02.190146..
Keywords: Guidelines, Evidence-Based Practice, Implementation, Prevention
Perry CK, Damschroder LJ, Hemler JR
Specifying and comparing implementation strategies across seven large implementation interventions: a practical application of theory.
This study used empirical data to test how the Expert Recommendations for Implementing Change (ERIC) taxonomy applies to a large dissemination and implementation initiative aimed at taking cardiac prevention to scale in primary care practice. The ERIC taxonomy was applied to the seven cooperatives funded by AHRQ鈥檚 EvidenceNOW initiative. The cooperatives' implementation strategies were identified using ERIC; a matrix of the specified ERIC strategies across the cooperatives was then mapped and compiled, and implementation strategies grouped according to outcomes and justifications. The findings suggest revisions to be made to the ERIC implementation strategies to reflect their utilization in real-work dissemination and implementation efforts.
AHRQ-funded; HS023940.
Citation: Perry CK, Damschroder LJ, Hemler JR . Specifying and comparing implementation strategies across seven large implementation interventions: a practical application of theory. Implement Sci 2019 Mar 21;14(1):32. doi: 10.1186/s13012-019-0876-4..
Keywords: Cardiovascular Conditions, Evidence-Based Practice, Prevention, Primary Care, Implementation
Meyers D, Miller T, Genevro J
大象视频Author: Meyers D, Miller T, Genevro J, Zhan C, De La Mare J, Fournier A, Bennett H, McNellis RJ
EvidenceNOW: Balancing primary care implementation and implementation research.
In 2015, 大象视频invested in the largest primary care research project in its history. EvidenceNOW is a $112 million effort to disseminate and implement patient-centered outcomes research evidence in more than 1,500 primary care practices and to study how quality-improvement support can build the capacity of primary care practices to understand and apply evidence. EvidenceNOW comprises 7 implementation research grants, each funded to provide external quality-improvement support to primary care practices to implement evidence-based cardiovascular care and to conduct rigorous internal evaluations of their work.
AHRQ-authored.
Citation: Meyers D, Miller T, Genevro J . EvidenceNOW: Balancing primary care implementation and implementation research. Ann Fam Med 2018 Apr;16(Suppl 1):S5-s11. doi: 10.1370/afm.2196.
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Keywords: Cardiovascular Conditions, Communication, Evidence-Based Practice, Heart Disease and Health, Patient-Centered Healthcare, Patient-Centered Outcomes Research, Prevention, Primary Care, Quality of Care, Quality Improvement, Implementation
Ono SS, Crabtree BF, Hemler JR
Taking innovation to scale in primary care practices: the functions of health care extension.
Health care extension is an approach to providing external support to primary care practices with the aim of diffusing innovation. EvidenceNOW was launched to rapidly disseminate and implement evidence-based guidelines for cardiovascular preventive care in the primary care setting. This article describes how cooperatives varied in their approaches to extension and provides early empirical evidence that health care extension is a feasible and potentially useful approach for providing quality improvement.
AHRQ-funded; HS023940.
Citation: Ono SS, Crabtree BF, Hemler JR . Taking innovation to scale in primary care practices: the functions of health care extension. Health Aff 2018 Feb;37(2):222-30. doi: 10.1377/hlthaff.2017.1100.
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Keywords: Primary Care, Implementation, Cardiovascular Conditions, Evidence-Based Practice, Healthcare Delivery, Practice Improvement, Quality Improvement, Quality of Care, Patient-Centered Healthcare, Patient-Centered Outcomes Research, Prevention
Doherty JA, Crelia SJ, Smith MW
大象视频Author: Mabry-Hernandez IR, Ngo-Metzger Q
Large health systems' prevention guideline implementation: a qualitative study.
In 2015, researchers conducted and analyzed interviews with quality leaders from eight hospital-based systems and one physician organization who explained organizational processes to adapt, adopt, disseminate, and incentivize adherence to preventive services guidelines. Nearly all have a formal process for reviewing and refining guidelines, developing clinician support, and disseminating the approved guidelines.
AHRQ-authored.
Citation: Doherty JA, Crelia SJ, Smith MW . Large health systems' prevention guideline implementation: a qualitative study. Am J Prev Med 2018 Jan;54(1s1):S88-s94. doi: 10.1016/j.amepre.2017.07.025.
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Keywords: Primary Care, Guidelines, Evidence-Based Practice, Prevention, Implementation, Healthcare Delivery
Soban LM, Kim L, Yuan AH
Organisational strategies to implement hospital pressure ulcer prevention programmes: findings from a national survey.
The researchers describe the presence and operationalisation of organisational strategies to support implementation of pressure ulcer prevention programmes across acute care hospitals in a large, integrated health-care system. Organisational strategies that support implementation of a pressure ulcer prevention programme (policy, committee, staff education, wound care specialists, and use of performance data) were reported at high level.
AHRQ-funded; HS000046.
Citation: Soban LM, Kim L, Yuan AH . Organisational strategies to implement hospital pressure ulcer prevention programmes: findings from a national survey. J Nurs Manag 2017 Sep;25(6):457-67. doi: 10.1111/jonm.12416.
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Keywords: Pressure Ulcers, Prevention, Hospitals, Patient Safety, Implementation, Organizational Change
Castro FG, Yasui M
Advances in EBI development for diverse populations: towards a science of intervention adaptation.
This introduction examines major issues and challenges as presented in this special issue of Prevention Science, "Challenges to the Dissemination and Implementation of Evidence Based Prevention Interventions for Diverse Populations." The authors describe the Fidelity-Adaptation Dilemma that generated controversies and debates and new perspectives on the dissemination and implementation of evidence-based interventions (EBIs) within diverse populations. The five articles in this special issue address many of these controversies and challenges.
AHRQ-funded; HS023007.
Citation: Castro FG, Yasui M . Advances in EBI development for diverse populations: towards a science of intervention adaptation. Prev Sci 2017 Aug;18(6):623-29. doi: 10.1007/s11121-017-0809-x.
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Keywords: Communication, Disparities, Evidence-Based Practice, Patient-Centered Outcomes Research, Prevention, Racial and Ethnic Minorities, Implementation
Hopkins AL, Moore-Monroy M, Wilkinson-Lee AM
It's complicated: negotiating between traditional research and community-based participatory research in a translational study.
The authors focused on the challenges, solutions, and lessons learned in applying the Interactive Systems Framework (ISF) to their translational research project. They identified challenges in the areas of research design, and in the ISF systems of prevention synthesis and translation, prevention support, and prevention delivery. They negotiated solutions between the scientific and local community that resulted in acceptable compromises for both groups. They concluded that although the model presented by the ISF is difficult to achieve, they offered concrete solutions to community members and scientists to move toward that ideal.
AHRQ-funded; HS022016.
Citation: Hopkins AL, Moore-Monroy M, Wilkinson-Lee AM . It's complicated: negotiating between traditional research and community-based participatory research in a translational study. Prog Community Health Partnersh 2016;10(3):425-33. doi: 10.1353/cpr.2016.0049.
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Keywords: Education: Patient and Caregiver, Depression, Prevention, Racial and Ethnic Minorities, Implementation
Singal AG, El-Serag HB
Hepatocellular carcinoma from epidemiology to prevention: Translating knowledge into practice.
The effectiveness of hepatocellular carcinoma (HCC) prevention in clinical practice and at the population level has lagged behind due to patient, provider, system, and societal factors. The authors suggest that the Quality in the Continuum of Cancer Care model provides a framework for evaluating the HCC prevention processes, including potential failures that create a gap between efficacy and effectiveness.
AHRQ-funded; HS022418.
Citation: Singal AG, El-Serag HB . Hepatocellular carcinoma from epidemiology to prevention: Translating knowledge into practice. Clin Gastroenterol Hepatol 2015 Nov;13(12):2140-51. doi: 10.1016/j.cgh.2015.08.014.
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Keywords: Cancer, Implementation, Prevention, Social Determinants of Health
Leeman J, Myers AE, Ribisl KM
Disseminating policy and environmental change interventions: insights from obesity prevention and tobacco control.
This paper describes the approach that two projects developed to disseminate policy and environmental change interventions. The Center for Training and Research Translation (Center TRT) disseminates evidence-based interventions (EBIs) to promote physical activity and healthy eating. Counter Tobacco disseminates EBIs to counter tobacco product sales and marketing in the retail environment.
AHRQ-funded; HS019468.
Citation: Leeman J, Myers AE, Ribisl KM . Disseminating policy and environmental change interventions: insights from obesity prevention and tobacco control. Int J Behav Med 2015 Jun;22(3):301-11. doi: 10.1007/s12529-014-9427-1..
Keywords: Communication, Evidence-Based Practice, Obesity, Policy, Prevention, Public Health, Tobacco Use, Implementation
Yawn BP, Bertram S, Kurland M
Repeated depression screening during the first postpartum year.
The researchers report a substudy of a large pragmatic trial of early post-partum depression screening and practice management, the Translating Research into Practice for Postpartum Depression (TRIPPD) study. They concluded that repeated PPD screening at 6 and 12 months鈥 postpartum increases the percentage of women identified as being at high risk of PPD.
AHRQ-funded; HS014744.
Citation: Yawn BP, Bertram S, Kurland M . Repeated depression screening during the first postpartum year. Ann Fam Med 2015 May-Jun;13(3):228-34. doi: 10.1370/afm.1777..
Keywords: Depression, Implementation, Screening, Prevention

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