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´óÏóÊÓƵResearch Studies

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Research Studies is a compilation of published research articles funded by ´óÏóÊÓƵor authored by ´óÏóÊÓƵresearchers.

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26 to 35 of 35 Research Studies Displayed
Blumenthal KG, Lai KH, Huang M
Adverse and hypersensitivity reactions to prescription nonsteroidal anti-inflammatory agents in a large health care system.
The researchers aimed to use electronic health record data to determine the incidence and predictors of hypersentivity reaction (HSR) to prescription nonsteroidal anti-inflammatory drugs (NSAIDs). They concluded that NSAID therapeutic use can be limited by adverse drug reactions (ADRs); about 1 in 5 NSAID ADRs is an hypersentivity reaction.
AHRQ-funded; HS022728.
Citation: Blumenthal KG, Lai KH, Huang M . Adverse and hypersensitivity reactions to prescription nonsteroidal anti-inflammatory agents in a large health care system. J Allergy Clin Immunol Pract 2017 May-Jun;5(3):737-43. doi: 10.1016/j.jaip.2016.12.006.
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Keywords: Electronic Health Records (EHRs), Medication, Risk, Health Systems, Adverse Drug Events (ADE)
Banerji A, Blumenthal KG, Lai KH
Epidemiology of ACE inhibitor angioedema utilizing a large electronic health record.
The objective of this study was to identify the incidence of and risk factors for angioedema caused by angiotensin-converting enzyme inhibitors (ACEIs) using a large integrated electronic health record (EHR). It concluded that the incidence of ACEI angioedema within a large EHR is consistent with large clinical trial data. A history of nonsteroidal anti-inflammatory drug allergy was identified as a risk factor for patients with ACEI angioedema.
AHRQ-funded; HS022728.
Citation: Banerji A, Blumenthal KG, Lai KH . Epidemiology of ACE inhibitor angioedema utilizing a large electronic health record. J Allergy Clin Immunol Pract 2017 May - Jun;5(3):744-49. doi: 10.1016/j.jaip.2017.02.018.
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Keywords: Electronic Health Records (EHRs), Medication, Risk, Health Information Technology (HIT), Adverse Drug Events (ADE)
Blumenthal KG, Acker WW, Li Y
Allergy entry and deletion in the electronic health record.
The researchers aimed to assess drug allergy entry, deletion, and accumulation, to identify health care professional types recording allergy data, and to assess the reaction types that lead to allergy entry and deletion. They found that of all allergies, 38.2 percent were immune mediated and 29.6 percent included only adverse effect reactions. Unavailable or unknown reactions comprised 32.2 percent of all allergies entered or deleted.
AHRQ-funded; HS022728.
Citation: Blumenthal KG, Acker WW, Li Y . Allergy entry and deletion in the electronic health record. Ann Allergy Asthma Immunol 2017 Mar;118(3):380-81. doi: 10.1016/j.anai.2016.12.020.
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Keywords: Data, Electronic Health Records (EHRs), Medication: Safety, Medication, Adverse Drug Events (ADE)
Horsky J, Aarts J, Verheul L
Clinical reasoning in the context of active decision support during medication prescribing.
The purpose of this study was to describe and analyze reasoning patterns of clinicians responding to drug-drug interaction alerts in order to understand the role of patient-specific information in the decision-making process about the risks and benefits of medication therapy. The investigators found that declining an alert suggestion was preceded by sometimes brief but often complex reasoning, prioritizing different aspects of care quality and safety, especially when the perceived risk was higher.
AHRQ-funded; HS021094.
Citation: Horsky J, Aarts J, Verheul L . Clinical reasoning in the context of active decision support during medication prescribing. Int J Med Inform 2017 Jan;97:1-11. doi: 10.1016/j.ijmedinf.2016.09.004..
Keywords: Adverse Drug Events (ADE), Adverse Events, Clinical Decision Support (CDS), Shared Decision Making, Electronic Health Records (EHRs), Health Information Technology (HIT), Medical Errors, Medication, Patient Safety
Zhou L, Dhopeshwarkar N, Blumenthal KG
Drug allergies documented in electronic health records of a large healthcare system.
The authors studied the prevalence of common drug allergies and patient characteristics documented in electronic health records of two large tertiary care hospitals in Boston from 1990 to 2013. They found that drug allergies in general were most prevalent among females and white patients, but that allergies to NSAIDs, ACE inhibitors, and thiazide diuretics were more prevalent in black patients.
AHRQ-funded; HS022728.
Citation: Zhou L, Dhopeshwarkar N, Blumenthal KG . Drug allergies documented in electronic health records of a large healthcare system. Allergy 2016 Sep;71(9):1305-13. doi: 10.1111/all.12881.
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Keywords: Adverse Drug Events (ADE), Electronic Health Records (EHRs), Medication: Safety, Medication
Topaz M, Seger DL, Slight SP
Rising drug allergy alert overrides in electronic health records: an observational retrospective study of a decade of experience.
The authors aimed to explore the common drug allergy alerts over the last 10 years and the reasons why providers tend to override these alerts. They found that alarmingly, alerts for immune mediated and life threatening reactions with definite allergen and prescribed medication matches were overridden 72.8 percent and 74.1 percent of the time, respectively.
AHRQ-funded; HS022728.
Citation: Topaz M, Seger DL, Slight SP . Rising drug allergy alert overrides in electronic health records: an observational retrospective study of a decade of experience. J Am Med Inform Assoc 2016 May;23(3):601-8. doi: 10.1093/jamia/ocv143.
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Keywords: Electronic Health Records (EHRs), Adverse Drug Events (ADE), Medication, Medication: Safety, Patient Safety
Topaz M, Lai K, Dhopeshwarkar N
Clinicians' reports in electronic health records versus patients' concerns in social media: A pilot study of adverse drug reactions of aspirin and atorvastatin.
The study’s objective was to compare electronic health record data and social media data to better understand differences and similarities between clinician-reported adverse drug reactions (ADRs) and patients' concerns regarding aspirin and atorvastatin. It found that the most frequently reported ADRs matched the most frequent patients' concerns. However, several less frequently reported reactions were more prevalent on social media (i.e., aspirin-induced hypoglycemia was discussed only on social media).
AHRQ-funded; HS022728.
Citation: Topaz M, Lai K, Dhopeshwarkar N . Clinicians' reports in electronic health records versus patients' concerns in social media: A pilot study of adverse drug reactions of aspirin and atorvastatin. Drug Saf 2016 Mar;39(3):241-50. doi: 10.1007/s40264-015-0381-x..
Keywords: Electronic Health Records (EHRs), Social Media, Health Information Technology (HIT), Adverse Drug Events (ADE), Patient Safety
Pohl JM, Tanner C, Hamilton A
Medication safety after implementation of a commercial electronic health record system in five safety-net practices: a mixed methods approach.
This study, conducted in five safety-net practices, examined the impact of implementing a commercial electronic health records system on medication safety. The authors found 130 "true" drug-drug interaction (DDI) pairs, representing 149,087 visits and 62 providers, with the largest DDI categories being related to antihypertensive medications, which are often prescribed together. They found no significant differences between physicians and nurse practitioners on the rate of DDI pairs.
AHRQ-funded; HS017191.
Citation: Pohl JM, Tanner C, Hamilton A . Medication safety after implementation of a commercial electronic health record system in five safety-net practices: a mixed methods approach. J Am Assoc Nurse Pract 2014 Aug;26(8):438-44. doi: 10.1002/2327-6924.12089.

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Keywords: Medication: Safety, Medication, Electronic Health Records (EHRs), Health Information Technology (HIT), Adverse Drug Events (ADE), Adverse Events, Medical Errors, Patient Safety
Kirkendall ES, Spires WL, Mottes TA
Development and performance of electronic acute kidney injury triggers to identify pediatric patients at risk for nephrotoxic medication-associated harm.
The authors described an approach and provided a technical framework for the creation of risk-stratifying acute kidney injury (AKI) triggers and the development of an application to manage the AKI trigger data. Their report summarizes the construction of a trigger-based application, the performance of the triggers, and the challenges uncovered during the design, build, and implementation of the system.
AHRQ-funded; HS021114.
Citation: Kirkendall ES, Spires WL, Mottes TA . Development and performance of electronic acute kidney injury triggers to identify pediatric patients at risk for nephrotoxic medication-associated harm. Appl Clin Inform 2014 Apr 2;5(2):313-33. doi: 10.4338/aci-2013-12-ra-0102.
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Keywords: Adverse Drug Events (ADE), Children/Adolescents, Medication, Health Information Technology (HIT), Electronic Health Records (EHRs)
Encinosa WE, Bae J
´óÏóÊÓƵAuthor: Encinosa WE
Will meaningful use electronic medical records reduce hospital costs?
The authors examined what impact the 5 core medication meaningful use (MU) criteria have on hospital-acquired adverse drug events (ADEs) and their costs in 2010, as a baseline for the start of MU implementation in 2011. They developed a quality indicator to track in-hospital ADEs and concluded that the adoption of core medication MU elements will cut ADE rates, with cost savings that recoup 22% of information technology costs.
AHRQ-authored.
Citation: Encinosa WE, Bae J . Will meaningful use electronic medical records reduce hospital costs? Am J Manag Care 2013 Nov;19(10 Spec No):eSP19-25.
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Keywords: Adverse Drug Events (ADE), Electronic Health Records (EHRs), Healthcare Costs, Healthcare Cost and Utilization Project (HCUP), Medication

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